The core idea
The 2s10s spread is the ten-year Treasury yield minus the two-year Treasury yield. It summarizes the slope between a policy-sensitive maturity and a major long-term benchmark.
What is happening underneath
A negative spread means that segment is inverted.
How investors should read it
Its change can reflect both near-term Federal Reserve expectations and long-term growth, inflation and term-premium pricing.
The same market move can carry different information depending on which maturity, issuer and risk premium is changing. Read the question together with the underlying concepts rather than treating one price move as a universal signal.